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However, some unwanted effects have been reported in animal studies. Patients who develop this
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syndrome may have high fevers, muscle rigidity, altered mental status, irregular pulse or blood pressure, rapid heart rate, excessive sweating, and heart arrhythmias. As with other anti-psychotics, long-term use of aripiprazole may lead to a potentially irreversible condition called tardive
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dyskinesia (involuntary genital herpes images movements
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of the jaw, lips, and tongue). Kalvin 18 more aripiprazole related articles ... Moreover, like other anti-psychotics, it blocks several receptors on the nerves of the brain for several neurotransmitters (chemicals that nerves use to communicate
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with each other). Alpha-1 receptor blockers [doxazosin (Cardura), prazosin (Minipress), terazosin (Hytrin), used for control of
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blood pressure and prostatic enlargement, may increase the zachery of hypotension (unusually low blood pressure). Itraconazole (Sporanox), fluconazole (Diflucan), voriconazole (Vfend), cimetidine (Tagamet), verapamil (Calan; Isoptin); diltiazem (Cardizem; herpes simplex genital herpes Dilacor), erythromycin, clarithromycin (Biaxin),
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nefazodone (Serzone), ritonavir (Norvir), saquinavir (Invirase), nelfinavir (Viracept), indinavir (Crixivan), and grapefruit juice. Ketoconazole (Nizoral) can increase the amount of aripiprazole in the body by blocking CYP3A4. Other drugs that can promote the activity
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of CYP3A4 and decrease the body's levels of aripiprazole
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are phenytoin (Dilantin), rifampin (Rifadin, Rimactane, Rifadin, Rifater, Rifamate), and phenobarbital. It is not known if aripiprazole is excreted in breast milk; however, since most medicines are excreted in breast milk, it is recommended
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that women receiving aripiprazole should not breast feed. Aripiprazole is used to treat schizophrenia, bipolar mania and mixed manic/depressisve episodes (as sole or adjunctive therapy) and as adjunctive (add-on) therapy for major depressive disorder. Aripiprazole can be taken with or without food. Some of the most com side effects associated with aripiprazole
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are
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anxiety, blurred vision, constipation, cough, headache, insomnia, lightheadedness, nausea, rash, restlessness, runny nose, sleepiness, tremors, vomiting, weakness, and weight gain. The physician may chose to use aripiprazole if he or she feels that it its benefits outweigh this potential concern. Quinidine (Quinaglute, Quinidex) inhibits another liver enzyme known as CYP2D6
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that also breaks down aripiprazole and can increase the amount of aripiprazole in the body. Aripiprazole is an anti-psychotic drug for treating psychoses. The manufacturer of aripiprazole recommends reducing the dose of aripiprazole by one-half during quinidine therapy. A potentially fatal complex referred to as neuroleptic malignant syndrome has been reported
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with anti-psychotic drugs, including aripiprazole. Its effects on these receptors are complex, involving stimulation of the receptors but to a lesser degree than the naturally-occurring neurotransmitters (a process called partial agonism). Like other anti-psychotic drugs, the mechanism of action of aripiprazole is unknown. Carbamazepine (Tegretol) can markedly decrease the
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amount of aripiprazole in the body by increasing the rate at which the body's enzymes (particularly the liver enzyme, CYP3A4) degrade it. The dose may be increased over time to achieve the desired effect. 1 2 3 Next aripiprazole Index Glossary Report Problems to the Food and Drug Administration You are encouraged to report negative side effects of prescription drugs to the FDA. The manufacturer of aripiprazole recommends reducing the dose of aripiprazole by one-half during ketoconazole therapy. The manufacturer recommends that patients on aripiprazole who are started on carbamazepine double their dose of aripiprazole, under their doctor's supervision.
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Monthly Shot Treats Schizophrenia Antipsychotics in Kids May Add Weight Abilify Approved for Children With Bipolar Disorder Abilify Approved as Additional Treatment for Major Depression. Printer-Friendly Format Email to a Friend From the Doctors at Schizophrenia - Get information on schizophrenia symptoms (delusions, hallucinations), causes (genetics), diagnosis, treatment of schizophrenics (antipsychotic drugs) and types (paranoid). Other medicines that block CYP2D6 include fluoxetine (Prozac) and paroxetine (Paxil). The
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FDA approved aripiprazole in November 2002. Aripiprazole usually is taken once a day. Tablets should be stored at room temperature, 15-30 C (59-86 F). The usual starting dose is 10 or 15 mg once daily. It is thought that its beneficial effect is due to its effects on dopamine and serotonin receptors. Aripiprazole has not been studied in pregnant women. Visit the FDA website or call 1-800-FDA-1088.

Many other drugs also are known to block CYP3A4 and potentially could increase the levels of aripiprazole, but their actual effects on aripiprazole levels have not been studied.